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Depression

What is depression?

Depression is a mental state characterized by a pessimistic sense of inadequacy and a despondent lack of activity. Common are feelings of sadness, despair, anxiety, emptiness, hopelessness, helplessness, loss of energy, and difficulty dealing with normal daily life.

Related Chemicals
Citalopram
Diphenhydramine

Antidepressants May Damage Cranial Nerves
by Quinta Essentia

Do antidepressants damage nerves in the brain? Well, possibly. But don't jump to any conclusions. According to Gary Null, Ph. In this manner, the (receiving) post-synaptic receptors get bombarded with serotonin. , all this over stimulation causes a decrease in the number of post-synaptic receptors. D. As a result, a lot of excess firing takes place and therefore more serotonin remains in the synaptic cleft. They prevent serotonin from being removed from the synaptic cleft. SSRI-AntiDepressants certainly don't raise your serotonin levels in a gentle manner.

The damage may be permanent or not. It is not established whether or not receptors ever come back after discontinuing an SSRI-AntiDepressant. Depending on the intensity and duration of blocking re-uptake, around 30% to 40% of the post-synaptic receptors will be eliminated (Eli Lilly, the manufacturer of Prozac, would knew about the disappearance of receptors from their laboratory experiments).

In studies with baboons who were treated with Ecstasy, researchers used Positron Emission Tomography (PET) to take brain scans of them. The researchers found that Ecstasy was toxic to the brain and damaged the axon terminals (nerve endings) of serotonergic neurons. This damage was still present in the baboons 7 years after discontinuing the drug. In a recent study, researchers saw marked changes in the axon terminals (nerve endings) of serotonergic neurons in rats, treated with SSRI-AntiDepressants. Likewise, the SSRI-AntiDepressant induced brain damage observed in the rats, could be present in humans as well. The terminals shrivelled or took on corkscrew shapes. Later studies in humans who had used Ecstasy, documented the same damage at serotonergic neurons as observed with the baboons. These changes were similar to those observed with the serotonin booster drug "Ecstasy" (MDMA). Apparently this is not the only neuro damage caused by SSRI-AntiDepressants.

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